This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.

This open access book examines the triangle between family, gender, and health in Europe from a demographic perspective. It helps to understand patterns and trends in each of the three components separately, as well as their interdependencies. It overcomes the widely observable specialization in demographic research, which usually involves researchers studying either family or fertility processes or focusing on health and mortality. Coverage looks at new family and partnership forms among the young and middle-aged, their relationship with health, and the pathways through which they act. Among the old, lifelong family biography and present family situation are explored. Evidence is provided that partners advancing in age start to resemble each other more closely in terms of health, with the health of the partner being a crucial factor of an individual’s own health. Gender-specific health outcomes and pathways are central in the designs of the studies and the discussion of the results. The book compares twelve European countries reflecting different welfare state regimes and offers country-specific studies conducted in Austria, Germany, Italy - all populations which have received less attention in the past - and Sweden. As a result, readers discover the role of different concepts of family and health as well as comparisons within European countries and ethnic groups. It will be an insightful resource for students, academics, policy makers, and researchers that will help define future research in terms of gender and public health.

Workflow graphs extend classical flow charts with concurrent fork and join nodes. They constitute the core of business processing languages such as BPMN or UML Activity Diagrams. The activities of a workflow graph are executed by humans or machines, generically called resources. If concurrent activities cannot be executed in parallel by lack of resources, the time needed to execute the workflow increases. We study the problem of computing the minimal number of resources necessary to fully exploit the concurrency of a given workflow, and execute it as fast as possible (i.e., as fast as with unlimited resources). We model this problem using free-choice Petri nets, which are known to be equivalent to workflow graphs. We analyze the computational complexity of two versions of the problem: computing the resource and concurrency thresholds. We use the results to design an algorithm to approximate the concurrency threshold, and evaluate it on a benchmark suite of 642 industrial examples. We show that it performs very well in practice: It always provides the exact value, and never takes more than 30 ms for any workflow, even for those with a huge number of reachable markings.

Big data is closely linked to the new, old question of data quality. Whoever pursues a new research perspective such as big data and wants to zero out irrelevant data is confronted with questions of data quality. Therefore, the European General Data Protection Regulation (GDPR) requires data processors to meet data quality standards; in case of non-compliance, severe penalties can be imposed. But what does data quality actually mean? And how does the quality requirement fit into the dogmatic systems of civil and data protection law?

This open access book is an outcome of the collaboration between the Soil and Water Management & Crop Nutrition Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria, and the International Center for Biosaline Agriculture (ICBA), Dubai, UAE. The objective of this book is to develop protocols for salinity and sodicity assessment and develop mitigation and adaptation measures to use saline and sodic soils sustainably. The focus is on important issues related to salinity and sodicity and to describe these in an easy and user friendly way. The information has been compiled from the latest published literature and from the authors’ publications specific to the subject matter. The book consists of six chapters. Chapter 1 introduces the terms salinity and sodicity and describes various salinity classification systems commonly used around the world. Chapter 2 reviews global distribution of salinization and socioeconomic aspects related to salinity and crop production. Chapters 3 covers comprehensively salinity and sodicity adaptation and mitigation options including physical, chemical, hydrological and biological methods. Chapter 4 discusses the efforts that have been made to demonstrate the development of soil salinity zones under different irrigation systems. Chapter 5 discusses the quality of irrigation water, boron toxicity and relative tolerance to boron, the effects of chlorides on crops. Chapter 6 introduces the role of nuclear techniques in saline agriculture.